Scientist

Description

100% Onsite

No PhD candidates

100% Onsite

PhD will be overqualified

BS or MS in with 1-3 + (BS) years with relevant exp. (Chemistry/Biochemistry)

• Perform cell viability assessments
• qPCR
• No animal handling work
• Running cyp induction assays
• Looking for exp in cyp induction, qPCR and cell culture
• Plating cell
• Dosing cells with compound
• RNA extraction
• Automated liquid handling systems exp is a plus

What are the top 3-5 skills, experience or education required for this position?

• CYP induction assay
• in vitro ADME
• qPCR
• Cell culture
• liquid handling system

Education:         

• BS (1-3 years relevant experience) or MS in Biochemistry, Chemistry or Biology

In what type of environment would this individual be working :Lab based

General Position Summary/Purpose:

Client is seeking a highly motivated fulltime contract Scientist to join the In Vitro Sciences group . 

• The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays.
• QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
• In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes.  Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Core Job Responsibilities:

• Routinely conduct (hands-on) evaluation of CYP450 induction
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human and rodent hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use microplate reader to measure endpoints
• Contribute to the design of invitro ADME assays and data interpretation
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Use BioELN and GraphPad Prism for data analysis