Scientist

Description

Job Description

• The Client is seeking a highly motivated scientist for initiating the lentiviral delivery platform for gene therapy in a newly established Genetic Medicine team.
• The candidate will work collaboratively with cross-functional and therapeutic area teams to advance company’s lentiviral gene therapy pipeline.
• The ideal candidate will have strong expertise and experience in lentivirus vector engineering, production, analytics and in vitro screening, as well as experience in managing CROs for lentiviral production.

Key Responsibilities Include:

• Collaborate with cross-functional and therapeutic area teams to advance novel lentiviral vectors into pipeline
• Design and engineer lentiviral vectors and manage lentiviral production by leveraging internal and CRO resources.
• Help build and establish analytical and cell-based screening assays (e.g., p24, VCN, SupT1 titration, ELISA, qPCR, ddPCR, WES, FACS, and endotoxin assay)
• Maintain a comprehensive Electronic Lab Notebook documenting experiments
• Maintain a high level of productivity in the team with clear daily, detailed, and accurate documentation of experiments
• Author technical reports and protocols
• Understand and enforce company culture, teamwork, safety, appropriate handling of materials in an BSL2 environment
• Perform all activities in compliance with applicable regulations, Client’s policies and guidelines
• Bring a "can do" spirit to work and deliver on other responsibilities as assigned

Qualifications

• Ph.D. in biology or a relevant field with 5+ years of experience in lentiviral vector-based gene therapy in addition to post-doctoral experience; or MS with at least 10 years of relevant experience; industrial experience highly desired
• Strong expertise and experience in lentiviral vector design, engineering and production
• Experience in managing CROs for lentiviral production
• Experience in analytical and screening methods for characterization of lentiviral vector products
• Experience in CAR-T cell therapy
• Experience in in vivo lentiviral targeted delivery is a plus
• Ability to work effectively in a highly collaborative and dynamic environment
• Excellent verbal and written communication skills
• Excellent organization and collaborative skills
• Detail oriented with a passion to deliver quality results