Downstream Associate Scientist

Description

Position Summary/ Position Responsibilities

We are looking for a Downstream Scientist to join the Manufacturing Sciences and Technology (MSAT) organization at Client based out of Andover, MA. The MSAT downstream purification team supports purification process development and optimization for commercial processes and next generation process development.

This person will be expected to develop and qualify purification techniques, ensure the proper and timely execution of purification processing, and perform scale-down purifications of biologics using a variety of unit operations, such as precipitation, depth filtration, TFF, and chromatography.

• Process development and characterization for vaccine programs and second-generation processes using various purification techniques.
• Plan, design, and execute downstream experiments to enable technology transfer of vaccine programs and second-generation purification processes.
• Operation and maintenance of downstream equipment and associated analytical tools.
• Data analysis, technical writing, reporting, and presenting to internal teams.
• Support manufacturing investigations and purification process troubleshooting.
• Drive lab improvement, 5S, standardization initiatives within department.
• Plan, prepare, execute, and conclude critical vaccine material production campaigns.
• Collaborate with project team to divide responsibilities and communicate results.
• Emphasize teamwork and cross functional learning/training of new skills.

Education And Experience

• Bachelor’s degree in a relevant discipline with at leaset 3 years of applicable bioprocess experience.
• Experience with mRNA drug substance process (such as in-vitro transcription reactions), Enzyme based process, and purification of biomolecules (such as Enzymatic reactions, AKTA, UF/DF, Column Chromatography)
• Famililary working in GxP cross matrix organizations
• Lab-scale purification process development and troubleshooting experience with standard downstream equipment (e.g. AKTAs, Repligen TFF, etc…)
• Experience and knowledge of templated processes such as mAbs
• Experience with mRNA Lipid Nano Particle (LNP) formulation and final Drug Product (DP)