Scientist

Description

100% Onsite

Length of Contract     6 months +

General Position Summary/Purpose:

• The DMPK-BA department is seeking a highly motivated fulltime DMPK Scientist to join the In Vitro ADME Sciences group (IVAS).
• The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and also may work on other in vitro ADME assays.
• DMPK-BA works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
• In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays primarily including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes.
• Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Core Job Responsibilities:

• Routinely conduct (hands-on) evaluation of CYP450 induction
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use  microplate reader to measure endpoint
• Contribute to invitro ADME assay design and discussions
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Use BioELN and GraphPad Prism for data analysis

What is a nice to have (but not required) skill, experience, education, or certification? 

• BS or MS in with 3-5 + (BS) Ph.D. with 0+ years with relevant exp. In their PhD program (Chemistry/BioChemistry)