Senior Scientist- Proteogenomics Approaches for Novel Antigen Discovery

Description

About the job

• We are seeking a highly motivated Senior Scientist who will use our pioneering facilities and technology to perform qualitative and quantitative mass spectrometry experiments focusing on autoimmune, infectious disease, and oncology targets for novel Immunotherapeutics such as bispecific antibodies, cell therapies, and vaccine approaches.
• You will be to apply the latest mass spectrometry techniques for the discovery and validation of novel disease specific antigens from human tissues and cell lines as well as to develop innovative techniques and investigate innovative technologies to enhance our target discovery efforts.

As a Senior Scientist, a Typical Day Might Include

• Running mass spectrometry-derived data analysis (total proteomics, cell surface proteomics, immunopeptidomics)
• Carrying out method development and optimization, including automation of current technologies
• Preparing MS samples from a variety of normal, diseased and tumor samples, including sample pre-fractionation and proteolytic digestion
• Conducting affinity purification of endogenous proteins/peptides from a variety of samples (i.e., patient tissue biopsies, animal specimens, and cultured cells)
• Working closely within and across scientific fields to design and perform analyses
• Presenting data packages and conclusions to internal and external collaborators; preparing results for presentation at conferences and publication

This Role Might Be For You If You Have

• Strong organizational skills and attention to detail
• Able to work effectively in a fast-paced industry environment
• Self-motivated, self-disciplined, and able to function independently, as well as part of a team
• Strategic agility, strong critical thinking and problem solving
• Ability to prioritize, multi-task, and work in an evolving environment

In order to be considered for this role, :

• You must have at least a Ph.D in biology, biochemistry, biotechnology, or related field with 0-3 years of relevant experience or a BS/MS with 8-10+ years.
• Skill in the operation of an HPLC and mass spectrometer (LC-MS) is required.
• Experience with various mass spectrometry instrumentation such as Thermo Orbitrap series and Bruker Ultra series is strongly preferred.
• Knowledge in autoimmunity and immunology desirable.
• Experience with sample preparation for immunoprecipitation for MS analysis is required.
• Data analysis of raw MS data analysis using Xcalibur, PEAKS, Spectronaut, FragPipe, Skyline and general DB search engine tools preferred.
• Prior Immunopeptidomics experience is a plus.
• Expertise in large-scale data analysis of NGS (Whole Exome sequencing, RNA-seq, RiboSeq and MS proteomics) is a plus.