Scientist

Description

What are the top 3-5 skills, experience or education required for this position? 

• CYP induction assay
• in vitro ADME
• qPCR
• Cell culture
• liquid handling system

Education:         

• BS (1-3 years relevant experience) or MS in Biochemistry, Chemistry or Biology

In what type of environment would this individual be working   : Lab based

General Position Summary/Purpose:

• The client is seeking a highly motivated fulltime contract Scientist to join the In Vitro ADME Sciences group (IVAS). 
• The successful candidate will work in collaboration with other team members to characterize the CYP Induction properties of candidate drug molecules and may work on other in vitro ADME assays.
• Client works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
• In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays including CYP450 induction assays to characterize candidate drug molecules for potential to induce CYP450 enzymes. 
• Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Core Job Responsibilities:

• Routinely conduct (hands-on) evaluation of CYP450 induction
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human and rodent hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use microplate reader to measure endpoints
• Contribute to the design of invitro ADME assays and data interpretation
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Use BioELN and GraphPad Prism for data analysis