Scientist

Description

• Primary cell culture and functional assays (T cell, myeloid cell)
• flow cytometry (experiment and data analysis)
• ELISA or MSD or HTRF
• Bachelor or master degree with 2-3 yrs experience in Biotech/pharm setting
• Strong scientific ethics

Immunology Discovery

Location: Cambridge, MA

We are currently seeking a highly motivated and passionate scientist to join our team in Immunology Discovery department.

• The candidate will focus on generating biology data package to help advance target identification and validation within GI immunology.
• The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery.
• The scientist will focus on developing and optimizing cellular/molecular assays to generate reliable and reproducible data in a timely manner.
• The scientist is expected to read and adapt scientific literature and internal protocols to accomplish assignments and demonstrate broad and versatile technical expertise within immunology.
• The position requires ability to work independently, have excellent technical, written and oral communication skills and work very well in a collaborative team environment.

Key responsibilities

• Develop cell-based functional assays using cell lines and mammalian tissue primary cells
• For functional assays, measure readouts including cell activation, differentiation and effector molecule secretion
• Perform advanced molecular and cellular biology techniques (including but not limited to FACS, ELISA, MSD, HTRF)
• Isolate and culture immune cells from relevant human and mouse tissues
• Work with non-immune cells and develop relevant assays to evaluate interactions with immune cells that are relevant to the project
• Work independently on the design, execution and interpretation of experimental results to validate hypotheses related to the project need
• Implement and innovate new experimental protocols/techniques as needed
• Analyze, interpret, document and report data consistently, concisely and rigorously, both to individual stakeholders and in group settings
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment
• Impact projects mostly through lab-based activities

Qualifications and requirements:

• The applicant must have a bachelor’s degree or master’s degree in Biological Science or related field with 3-5 years of experience in biotech or pharma set up.
• Experience in in vitro cell culture (sterile techniques, handling challenging cell types) and cell-based assays development is required.
• Experience with immune cells including T cells and myeloid cells (monocytes or dendritic cells) is required.
• Experience in immunoassays including multi-color flow cytometry and ELISA (or MSD, HTRF) is required.
• Experience with non-immune cells including fibroblasts and epithelial cells is a plus but not required.
• Knowledge of DNA/RNA handling and other molecular biology techniques like PCR and qPCR is a plus.
• Ability to learn new skills and apply them in a fast-paced research enviroment.
• Creativity, problem-solving, and attention to details.
• Excellent oral and written communication and collaboration skills.
• Ability to work independently as well as in a team.
• Proven flexibility to deal with changing timelines and shifting work priorities.