Reports to: Scientist II, Analytical Research

Location: San Carlos, CA

Work Arrangement: On-site (at least 4 days/week)

ASSOCIATE SCIENTIST II, BIOANALYTICAL, RESEARCH

Summary:

• You will participate in cross-functional teams to work on multiple projects.
• Main responsibilities include using multiple analytical assays to characterize protein, polysaccharide and conjugates in support of various bacterial vaccine initiatives.
• This bench-based position and the successful candidate will be focused on performing and developing analytical plate-based assays.
• The candidate will have the opportunity to work with external collaborators as well as present at team meetings and assist in authoring internal and external publications.

Essential Functions:

• Conduct analytical characterization of protein, polysaccharide, and conjugated analytes using established methods - e.g. HPLC, SEC-MALS, CE-SDS, cIEF, plate-based assays (BCA, residual DNA, anthrone), ELISA, SDS-PAGE, western blot
• Screen monoclonal antibodies from external CRO and assist with shipping/receiving of related materials.
• Assist with development, optimization, and transfer of analytical assays that may come up as necessary in support of pipeline projects.
• Document experimental results and maintain electronic laboratory notebook (ELN) in compliance with company policies.
• Author technical reports, protocols, and SOPs
• Present findings to team and department meetings.
• Support in routine laboratory activities (e.g., laboratory inventory, ordering/procuring standards, preparation of solutions and media as necessary).
• Stay current on scientific literature and emerging technologies within area of expertise/interest.

Requirements:

• B.S. with a minimum of 4 years of industry experience or a M.S. with 0-2 years of industry experience.
• Hands-on experience with biochemistry and biomolecular analytical methods with proficiency in HPLC, SEC-MALS, plate-based assays (BCA, lowry, picogreen, anthrone,), ELISA, SDS-PAGE, western blot.
• Ability to contribute to the overall lab management, including reagent and sample organization.
• Proficiency in running multiple projects and demonstrated success working in a cross-functional team environment.
• Knowledge of general chemistry principles coupled with problem-solving abilities and attention to detail.
• Good interpersonal skills, with excellent written and verbal communication skills.
• General computer skills, Microsoft Office products (experience with scientific software is a plus).
• Familiarity with Good Laboratory Practices.
• Excellent organizational and time-management skills.
• Specific experience in conjugate vaccine development a plus.